Tetracyclines inhibit activated B cell function

Retinal pericytes inhibit activated T cell proliferation.

PURPOSE To test the hypothesis that retinal pericytes (RPCs) are immunosuppressive; therefore, their loss of function under hyperglycemic conditions favors retinal inflammation and contributes to the pathogenesis of diabetic retinopathy (DR). METHODS Isolated mouse and human RPCs were tested in T cell function assays to evaluate their capability of inhibiting T cell responses. To elucidate th...

Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.

A seminal experiment involving a germ-free rat model of connective tissue breakdown (followed soon thereafter by a series of in vitro studies) identified an unexpected non-antimicrobial property of tetracyclines (TCs). This ability of TCs to inhibit matrix metalloproteinases (MMPs) such as collagenase was found to reflect multiple direct and indirect mechanisms of action, and to be therapeutica...

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas.

Diffuse large B-cell lymphoma (DLBCL) consists of at least 2 phenotypic subtypes; that is, the germinal center B-cell-like (GCB-DLBCL) and the activated B-cell-like (ABC-DLBCL) groups. It has been shown that GCB-DLBCL responds favorably to chemotherapy and expresses high levels of BCL6, a transcription repressor known to play a causative role in lymphomagenesis. In comparison, ABC-DLBCL has low...

Activated Monocytes Inhibit Legionella Multiplication

Legionella pneumophila, the agent of Legionnaires' disease, is a facultative intracellular pathogen (1). The bacter ium multiplies intracellularly in human monocytes, and under tissue culture conditions, multiplication is exclusively intraeellular (1). In previous studies, we investigated the role of humoral immuni ty in Legionnaires ' disease (2, 3). We found that virulent in vivo grown L. pne...

Classification: Neoplasia Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug resistant T-cell leukemia